产品货号：
Z13853
中文名称：
CXXC4抗体
英文名称：
Anti-CXXC4 Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-CXXC4 Antibody |
| 指标别名 | IDAX,IDAX,CXXC-type zinc finger protein 4,Inhibition of the Dvl and axin complex protein |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | ELISA,WB,IHC,IF |
| 基因名称 | CXXC4 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | CXXC4 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human CXXC4.The immunogen is located within amino acids 50 - 100 of CXXC4. |
| 计算分子量 | 21kDa |
| 成分 | CXXC4 Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | CXXC4 Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | CXXC4 is zinc finger protein that binds directly to the PDZ domain of DVL1,a protein involved in the Wnt signaling pathway,through its C-terminal region.CXXC4's interaction with DVL1 competes with DVL1-AXIN binding,although the affinity of DVL1 for CXXC4 is lower than that for AXIN.In mouse fibroblasts,CXXC4 suppressed Wnt3a induction of beta-catenin and inhibited Wnt3a-dependent TCF4 activation,suggesting that CXXC4 acts as a negative regulator of the Wnt signaling pathway and functions between DVL and beta-catenin.Recent reports suggest that decreased CXXC4 expression is associated with kidney cancer metastasis,cell proliferation,reduced apoptosis in response to cancer drugs,and upregulation of genes involved with proliferation,invasion and cell survival,suggesting that CXXC4 plays a critical role in tumor progression in kidney cancer. |
| Uniprot ID | Q9H2H0 |
| 基因名全称 | CXXC finger protein 4 |
| 蛋白名全称 | CXXC finger protein 4 |
| 推荐稀释比 | CXXC4 antibody can be used for detection of CXXC4 by Western blot at 1μg/mL.Antibody can also be used for immunohistochemistry starting at 10μg/mL.For immunofluorescence start at 20μg/mL.Antibody validated:Western Blot in human samples;Immunohistochemistry in human samples and Immunofluorescence in human samples.All other applications and species not yet tested. |
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